Nephrotoxic and ototoxic potential. Such mutation results in a structural alteration in the 30S subunit leading to a loss of affinity for streptomycin, so that the antibiotic can no longer bind its recognition site and inhibit protein synthesis. Share Your Word File Ethambutol, Pyrazinamide, Thioamides, Cycloserine, Para-aminosalicylic acid, Streptomycin, and Clofazimine are possibly effective. Rapidly absorbed after intramuscular injection with peak serum concentrations attained after 1 - 2 hours. The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Streptomycin. Mechanism of streptomycin action on bacteria: a unitary hypothesis. LD50=430 mg/kg (Orally in rats with Streptomycin Sulfate); Side effects include nausea, vomiting, and vertigo, paresthesia of face, rash, fever, urticaria, angioneurotic edema, and eosinophilia. Acetylsalicylic acid may decrease the excretion rate of Streptomycin which could result in a higher serum level. TOS4. [PMC free article] DAVIES J, GILBERT W, GORINI L. STREPTOMYCIN, SUPPRESSION, AND THE CODE. streptomycin: ChEBI ID CHEBI:17076: Definition A amino cyclitol glycoside that consists of streptidine having a disaccharyl moiety attached at the 4-position. Case of Mycobacterium tuberculosis] Ann Inst Pasteur (Paris). Streptomycin induced K + flux is MscL-dependent. Drug created on June 13, 2005 07:24 / Updated on January 23, 2021 21:03. It acts by binding to the 30S ribosomal subunit of susceptible organisms and disrupting the initiation and elongation steps in protein synthesis. The antibiotic streptomycin is widely used in the treatment of microbial infections. 2007 Feb;63(4):1096-106. High frequency hearing loss precedes low frequency hearing loss. Used in the systemic treatment of infections. The Mechanism of Action of Streptomycin. [PMC free article] SPOTTS CR, STANIER RY. Feero, W. Gregory; Guttmacher, Alan E.; Dietz, Harry C. (2010). Mechanism of bactericidal action of aminoglycosides. Early studies trying to determine the mechanism of action of streptomycin indeed found that upon drug treatment a rapid flux of K + out of the cell was observed prior to any decrease in viability 15.Moreover, the same group describes a significant increase in streptomycin uptake if the bacteria are pre-diluted in a lower … Yeast: Origin, Reproduction, Life Cycle and Growth Requirements | Industrial Microbiology, How is Bread Made Step by Step? STREPTOMYCIN ACTION AND THE RIBOSOME. Contraindications & Blackbox Warnings data. 5 - 6 hours in adults with normal renal function. Erythromycin and other macrolide antibiotics inhibit protein synthesis by binding to the 23S rRNA molecule (in the 50S ... Streptomycin: Streptomycin is effective against gram-negative bacteria, although it is also used in the treatment of tuberculosis. Content Guidelines 2. This information should not be interpreted without the help of a healthcare provider. Mechanism of streptomycin action on bacteria: a unitary hypothesis. [, Vila-Sanjurjo A, Lu Y, Aragonez JL, Starkweather RE, Sasikumar M, O'Connor M: Modulation of 16S rRNA function by ribosomal protein S12. Streptomycin exerts it`s bactericidal action against gram- negative organisms & some of gram positive organisms by inhibiting bacterial protein synthesis. About the Illustrations. Foreign Title : Sur le mécanisme de l'action de la streptomycine. Effect of streptomycin on the excretion of nucleotides by Escherichia coli Previous studies1 on the mechanism of the antibiotic action of streptomycin on Escherichia coli have shown that under certain conditions the lethal action of the antibiotic is inversely related to the inorganic phosphate concentration of the medium over a range of lO-3 to lO-5 M. 1997 Sep;72(9):507-13. Anti-TB Agents. Resistance to the other aminoglycosides by this mechanism is uncommon since they bind to multiple sites on both ribosomal subunits and high-level resistance cannot be selected by a single step. What are the factors which induce heart failure? This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This occurs when the antibiotic induced misreading of the genetic code … This leads to codon misreading, eventual inhibition of protein synthesis and ultimately death of microbial cells through mechanisms that are still not understood. This video is helpful to the pharmacy, medical and nursing students who are dealing with pharmacology. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Streptomycin is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. What is the significance of transpiration? Kanamycin, Capreomycin and Amikacin are injectable second-line. Bacteria develop resistance to it by substituting an amino acid in a cell-wall component, preventing vancomycin from binding This lesson explains what tetracyclines are, their mechanism of action and what bacteria and diseases are treated with tetracyclines. 1999 Aug;290(2):672-7. Streptomycin may decrease the excretion rate of Acarbose which could result in a higher serum level. Streptomycin Dependence Certain mutants grown in the presence of streptomycin become dependent on it. Killing the bacteria by interrupting the bacterial cell wall formation. A rating for the strength of the evidence supporting each drug interaction. Privacy Policy3. The risk or severity of adverse effects can be increased when Streptomycin is combined with Acetyldigitoxin. Streptomycin may decrease the excretion rate of Abacavir which could result in a higher serum level. Mechanism of action. 2010 streptomycin-342682 Drugs Drugs streptomycin 2003 /viewarticle/884212 Clinical Review Streptomycin is excreted by glomerular filtration. Streptomycin is actively transported into the bacterial cell where it binds to receptors present on the 30 S ribosomal subunit. (With Methods)| Industrial Microbiology, How is Cheese Made Step by Step: Principles, Production and Process, Enzyme Production and Purification: Extraction & Separation Methods | Industrial Microbiology, Fermentation of Olives: Process, Control, Problems, Abnormalities and Developments, The best answers are voted up and rise to the top. Mechanisms of Streptomycin Resistance: ... Nucleotides involved in tertiary structure inter- action resulting in pseudoknots are shown in gray and are connected by dotted lines. MECHANISM OF ACTION • Streptomycin is a protein synthesis inhibitor. J Pharmacol Exp Ther. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses. Nephrotoxicity is caused by accumulation of the drug in proximal renal tubular cells, which results in cellular damage. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. [, Kenney TJ, Churchward G: Cloning and sequence analysis of the rpsL and rpsG genes of Mycobacterium smegmatis and characterization of mutations causing resistance to streptomycin. [, Knuckley B, Luo Y, Thompson PR: Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. Streptomycin blocks normal initiation of protein synthesis. Antibiotic Spectrum of Streptomycin 3. For some drugs, the mechanisms of action have not been fully identified. A very interesting observation has been made in some streptomycin-resistant mutants and is called streptomycin- dependence. Streptomycin is the least nephrotoxic of the aminoglycosides owing to the small number of cationic amino groups in its structure. Tetracylines: Structure and Mechanism of Action | Antibiotics, 6 Antibiotics used in Inhibitors of Protein Synthesis, Chloramphenicol: Structure and Mechanism of Action | Antibiotics. Streptomycin is toxic to humans and other animals and causes side effects such as allergic responses, loss of hearing, nausea, and kidney damage. Action de la streptomycine sur les bactéries. 45.9. Streptomycin is a water-soluble aminoglycoside derived from Streptomyces griseus.It is marketed as the sulfate salt of streptomycin. It is active against both gram-positive and gram-negative bacteria. The peak serum concentration in individuals with kidney damage should not exceed 20 to 25 mcg/mL.The concurrent or sequential use of other neurotoxic and/or nephrotoxic drugs with streptomycin sulfate, including neomycin, kanamycin, gentamicin, cephaloridine, paromomycin, viomycin, polymyxin B, colistin, tobramycin and cyclosporine should be avoided.The neurotoxicity of streptomycin … Not absorbed in the GI tract. 1964 May; 51:883–890. X-ray crystallographic structure of the 30S ribosomal subunit with bound drug (purple, space-filling model , at center) protein secondary structure elements such as alpha-helices in bright green, and the RNA phosphodiester backbone shown in orange (and the ladder of base pairs in dark green and blue) Small amounts are excreted in milk, saliva, and sweat. 2007 May;189(10):3876-83. 1994 Oct;176(19):6153-6. Streptomycin, the first antibiotic to be discovered by random screening of soil organisms, is predominantly active against enterobacteria and M. tuberculosis. An effect category for each drug interaction. May also be used in combination with other drugs to treat tularemia (Francisella tularensis), plague (Yersia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit. Streptomycin Injection - Composition and Active Ingredients. The natural mRNA initiates the protein synthesis by using f-met however the synthetic mRNA doesn’t require the f … Streptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus. Microbiology and Molecular Biology Reviews, 1987 – Am Soc Microbiol. 341-350. For the treatment of tuberculosis. It has been found that streptomycin-susceptible bacteria may become resistant to the antibiotic by a single step mutation. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. New England Journal of Medicine 363 (9): 852–863. ... or nucleic acid synthesis. Streptomycin is a protein synthesis inhibitor. Streptomycin is bactericidal in action. Epub 2007 Oct 13. In streptomycin-dependent mutants of bacterial pathogen, protein synthesis fails to take place in absence of streptomycin. This website includes study notes, research papers, essays, articles and other allied information submitted by visitors like YOU. Streptomycin Sulfate Injection USP 1g/2.5ml, Injection, powder, lyophilized, for solution, 2,4-diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside, Mieskes KT, Rusch-Gerdes S, Truffot-Pernot C, Feldmann K, Tortoli E, Casal M, Loscher T, Rinder H: Rapid, simple, and culture-independent detection of rpsL codon 43 mutations that are highly predictive of streptomycin resistance in Mycobacterium tuberculosis. Bioorg Med Chem. 2007 Jul-Aug;1769(7-8):462-71. Dependence. Streptomycin is characterised chemically as an aminoglycoside antibiotic. Mechanism of Action of Streptomycin. If you believe you are experiencing an interaction, contact a healthcare provider immediately. 2008 Jan 15;16(2):739-45. Further toxicity may result in retrograde degeneration of the auditory nerve. Streptomycin is bactericidal and broad-spectrum antibiotic. Biochim Biophys Acta. Mechanism of Action of Streptomycin: Streptomycin, like other aminoglycosidic antibiotics (e.g., gentamycin, neomycin, kanamycin, tobramycin), inhibits protein synthesis in bacterial cells by binding to the 30S subunit of ribosomes. By doing so, the streptomycin causes a structural change which interferes with the recognition site of codon-anticodon interaction resulting in misreading of the genetic message carried by messenger RNA (mRNA). the mechanism of action and the chemical nature of the antimicrobial agents are crucial in the understanding of how . Arnold L. Demain, Kozo Nagaoka, "Derivatives of streptomycin and method of producing streptomycin derivatives by mutational biosynthesis." A severity rating for each drug interaction, from minor to major. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. View Biolab Streptomycin Sulfate mechanism of action for pharmacodynamics and pharmacokinetics details. Both guanido groups of streptidine are essential for the antibiotic activity and removal of one group reduces antibiotic activity upto 90%. Streptomycin is a protein synthesis inhibitor. This is a question and answer forum for students, teachers and general visitors for exchanging articles, answers and notes. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. Aminoglycosides like Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. DESCRIPTION. Proc Natl Acad Sci U S A. A unique ID assigned by the FDA when a product is submitted for approval by the labeller. Action on Bacteria. J Bacteriol. Aminoglycosides like Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. The absence of an interaction does not necessarily mean no interactions exist. Contact us to learn more about these and other features. Epub 2007 Apr 20. Disclaimer Copyright, Share Your Knowledge Start studying streptomycin. U.S. Patent US3993544, issued November 23, 1976. 45.11. Hypersensitivity to streptomycin or other aminoglycosides; severe hypersensitivity to sulfites; Concomitant live bacterial vaccines. Structure of Streptomycin 2. ... Neomycin, streptomycin an d kanamycin are examples of aminoglycosides. ATC Classification . A governmentally-recognized ID which uniquely identifies the product within its regulatory market. [, Fukuda M, Koga H, Ohno H, Ogawa K, Yang B, Miyamoto J, Tomono K, Kohno S: [Relationship between streptomycin susceptibility and rpsL mutations of Mycobacterium tuberculosis strains]. Microbiology, Medical Microbiology, Chemotherapeutic Agents, Antibiotics, Streptomycin. There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Mechanism of Action Streptomycin is a protein synthesis inhibitor. “New Therapeutic Approaches to Mendelian Disorders”. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit. Mol Microbiol. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome irreversibly, interfering with the binding of formyl-methionyl-tRNAto the 30S subunit. The primary mechanism of action is inhibition of translation by binding to the ribosome, ... . Acemetacin may decrease the excretion rate of Streptomycin which could result in a higher serum level. Am J Trop Med Hyg. The schematic representation of the mechanism of streptomycin dependence is shown in Fig. 2000 Jul-Aug;63(1-2):56-60. Which part of the male reproductive system store the sperm? [. 45.10. Streptomycin blocked the RNA synthesis directed by natural mRNA but not with the synthetic mRNA. Mechanism of Action 4. Streptomycin is inhibitory for several species of Mycobacterium and is an effective antibiotic for treatment of tuberculosis caused by M. tuberculosis. (iii) Streptoscamine (N-methyl-L-glycosamine) as shown in Fig. InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1, N-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy}-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl]guanidine, CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]2NC(N)=N)O[C@@H](C)[C@]1(O)C=O. Resistance to streptomycin can occur by this mechanism since this agent binds to a single site on the 30S subunit of the ribosome. I. Mechanism of Action. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Tubular cells may regenerate despite continued exposure and nephrotoxicity is usually mild and reversible. Mechanism of action. The parent of the streptomycin class: Stars This entity has been manually annotated by the ChEBI Team. 1964 Apr; 51:703–709. 1953 Sep;85(3):295-307. Mechanisms of action Streptomycin in complex with a bacterial ribosome. Author(s) : Linz, R. Mechanism of action of streptomycin in E. coli: interruption of the ribosome cycle at the initiation of protein synthesis L Luzzatto , D Apirion , D Schlessinger Proceedings of the National Academy of Sciences Jul 1968, 60 (3) 873-880; DOI: 10.1073/pnas.60.3.873 Like other members of the aminoglycoside family it has no useful activity against streptococci, anaerobes or … III. Crossref Wolfgang Stenzel, Über den Einfluß der Streptomycinresistenz auf die Virulenz von Shigellen und Coli-Shigella-Hybriden, Zeitschrift für Hygiene und Infektionskrankheiten, 10.1007/BF02153153, 148 , 2, (152-156), … The risk or severity of bleeding can be increased when Streptomycin is combined with Acenocoumarol. 4 Propargyl-type 1,3-dipolar organic compound, antibiotic antifungal drug, antibiotic fungicide, streptomycins (, Disseminated mycobacterium avium complex infection, J04AM — Combinations of drugs for treatment of tuberculosis, J04A — DRUGS FOR TREATMENT OF TUBERCULOSIS, A07 — ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS, Agents that produce neuromuscular block (indirect), Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents, Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index, Carbohydrates and carbohydrate conjugates, Propargyl-type 1,3-dipolar organic compounds, Infection, Mycobacterium Avium-Intracellulare, Patients Colonized by Klebsiella Pneumoniae, Human Immunodeficiency Virus (HIV) Infections, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), MS/MS Spectrum - DI-ESI-Ion Trap , Positive, MS/MS Spectrum - DI-ESI-Hybrid FT , Positive, splash10-001i-0000090000-37fcf4def2f5e472aa90, splash10-03di-0091010000-39300aec20bda5d23649, splash10-03di-0090000000-34b8374e2a80e4cb95ec, splash10-03xr-1090000000-0d28a95c3d70165872c6, splash10-014j-5190000000-87daef600d1a1a4b52d8, splash10-001i-0200090000-e3f4de9e437da47f8b50, splash10-01q9-0911281000-307d692fcab3f0a93c0a, splash10-03e9-0900250000-1e9e471e29850e7a3023, splash10-001i-0660090000-e0be715ff2ef7bceed6e, splash10-0udi-0090000000-da49dca8f3e875260220, splash10-0006-0090000000-51b8b9878643820d5652, splash10-0729-6940300000-cbd7d78f026f93380976, splash10-00dj-9750000000-ea4bfbc8bf26152232f7, splash10-00dj-9100000000-e44f835436ca5aa376a5, splash10-0usi-9040000000-4cb87273cf38a98ccf69, LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-001i-0000090000-f0c24196329215da6048, splash10-001i-0000090000-0de059c38cbd52e00cce, splash10-01q9-0182190000-46e9dfef9871c913947b, splash10-03dj-1391000000-ae846bc34742e8a119c8, splash10-0fdt-4790000000-c949fbfe981dc5f039e8. This region interacts with the wobble base in the anticodon of tRNA. Kekkaku. Streptomycin-dependence is thought to develop as a result of another mutation which causes an opposite distortion of the recognition site of the 305 subunit of ribosome. MIMS Class . Extended description of the mechanism of action and particular properties of each drug interaction. It binds to the small 16S rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit. Aceclofenac may decrease the excretion rate of Streptomycin which could result in a higher serum level. E. faecalis, E. faecium). Vestibular toxicity may result in vertigo, nausea and vomiting, dizziness and loss of balance. I. Know how this interaction affects the subject drug. The process involves 1. [, Okamoto S, Tamaru A, Nakajima C, Nishimura K, Tanaka Y, Tokuyama S, Suzuki Y, Ochi K: Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. Streptomycin, like other aminoglycosidic antibiotics (e.g., gentamycin, neomycin, kanamycin, tobramycin), inhibits protein synthesis in bacterial cells by binding to the 30S subunit of ribosomes. Highly purified streptomycin is nontoxic when given in small doses, but it appears to have a cumulative detrimental effect on nervous system when, given as a medication over long periods of time. J01GA01 - streptomycin ; Belongs to the class of aminoglycosides, streptomycin. Answer Now and help others. Similar to other aminoglycosides, it works by inhibiting bacterial protein synthesis through irreversible binding to the 30 S ribosomal subunit of susceptible bacteria. Speculation on this mechanism indicates that the binding of the molecule to the 30S subunit interferes with 50S sub… What is the significance of the Hardy-Weinberg equilibrium? [Mechanism of action of streptomycin. In this article we will discuss about:- 1. Share Your PDF File Accumulation causes irreversible damage to hair cells of the cochlea or summit of the ampullar cristae of the vestibular complex. The mechanism of inhibition of protein synthesis by streptomycin is schematically shown in Fig. Their growth is promoted rather than inhibited by the antibiotic. Proc Natl Acad Sci U S A. Dosing : 20-40 mg/kg (Maximum 1 g) IM once daily or 25-30 mg/kg (Maximum 1.5 g) IM given 2-3 times weekly. Welcome to BiologyDiscussion! J Bacteriol. Our mission is to provide an online platform to help students to share notes in Biology. Streptomycin may decrease the excretion rate of Acetaminophen which could result in a higher serum level. Share Your PPT File. It is bactericidal due to effects that are not fully understood. Otoxocity occurs via drug accumulation in the endolymph and perilymph of the inner ear. [, Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. [, Nishimura K, Hosaka T, Tokuyama S, Okamoto S, Ochi K: Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2). BD Davis. Epub 2007 Mar 23. Before sharing your knowledge on this site, please read the following pages: 1. Streptomycin may decrease the excretion rate of Aclidinium which could result in a higher serum level. Irving H. Goldberg, Mode of action of antibiotics, The American Journal of Medicine, 10.1016/0002-9343(65)90094-X, 39, 5, (722-752), (1965). It consists of three components linked glycosidically (by ether bonds): (i) Streptidine (inositol with two guanido groups). Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. Streptomycin is an aminoglycoside antibiotic, originally isolated from the bacteria Streptomyces griseus.It is the first discovered aminoglycoside antibiotic. Mechanisms that are still not understood are susceptible to aminoglycosides Harry C. 2010... Jan 15 ; 16 ( 2 ):739-45 specific 30S-subunit proteins and rRNA... Inhibiting bacterial protein synthesis by streptomycin is actively transported into the bacterial cell it. To provide an online platform to help students to Share notes in Biology biosynthesis. one group reduces activity... Of gram positive organisms by inhibiting bacterial protein synthesis and ultimately death of cells. 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